This assignment is a literature review. I had already completed Chapter 1 and Chapter 2 of the literature review. I have all the references in the old paper that I have attached as well, please utilize all the same references, tell me if there are any changes made to the references if needed. If any additional references are needed you may add them in and let me know. Ensure the paper is in APA 7 format. I will attach the specific assignment instructions below as well as attach the rubric. Also ensure that there is no plagiarism please. Utilize in text citations. 
Instructions:
Let’s begin Chapter 3
Chapter 3 – Analyzing evidence-based medicine (EBM) literature involves critically evaluating research studies, systematic reviews, and meta-analyses to determine their validity, relevance, and applicability to clinical practice. Here are some steps to guide you through the process:
Revisit your Clinical Research Question: What was your clinical research question (PICOT) or clinical issue addressed in the literature? This will help you understand the focus of the study and its relevance to clinical practice.
Evaluate Study Design: Review the study designs found in your literature review. Consider whether it is a randomized controlled trial (RCT), cohort study, case-control study, cross-sectional study, systematic review, meta-analysis, or other type of study. Different study designs have varying levels of evidence and potential biases.
Assess Methodological Quality: Evaluate the methodological quality of the study. Consider factors such as randomization, blinding, allocation concealment, sample size, follow-up duration, control for confounding variables, and measures to reduce bias. 
Examine Participants: Evaluate the characteristics of the study participants, including demographics, inclusion and exclusion criteria, baseline characteristics, and any relevant comorbidities. Consider whether the study population is representative of the patients seen in clinical practice.
Analyze Intervention and Comparison: Evaluate the intervention(s) being studied and the comparison group(s) used. Assess the relevance and clinical significance of the interventions, as well as the comparability of the groups.
Review Outcomes: Examine the primary and secondary outcomes measured in the study. Consider whether the outcomes are clinically relevant, objectively measured, and appropriately analyzed. Look for evidence of selective reporting or outcome switching.
Assess Results: Analyze the results of the study, including effect sizes, confidence intervals, p-values, and statistical significance. Consider the magnitude of effect and the clinical relevance of the findings. Look for consistency with prior research and the biological plausibility of the results.
Consider Confounding and Bias: Evaluate potential confounding factors and sources of bias in the study. Consider whether the authors adequately controlled for confounders and minimized bias in the study design, analysis, and interpretation of results.
Evaluate Generalizability: Assess the external validity or generalizability of the study findings to the broader patient population or clinical setting. Consider factors such as patient demographics, clinical settings, and healthcare practices that may influence the applicability of the findings.
Synthesize and Interpret Findings: Synthesize your analysis of the literature to determine the strength of the evidence and its implications for clinical practice. Consider the overall risk of bias, consistency of results across studies, and the balance of benefits and harms of the intervention.
Conclusion: Develop an overall summary of chapter 3. 
By following these steps, you can systematically analyze evidence-based medicine literature to inform clinical decision-making and enhance patient care.